Black Spiderman Suit:
Defeat Venom at the grand finale mission to get the Black Spiderman Suit as a unlockable

Unlock Arena Mode:
Complete the game to unlock Arena mode under the extras option.

Defeating Michael:
When you are trying to open the boarded up windows, if you are far away from him he will do a long jump towards you. Then it takes him a few seconds to recover to attack. Before he jumps, do not stand in the yellow circles. Instead, stand next to the wall opposite the windows. He will now jump to there, recover, etc. While he is recovering, pull down the boards. When he jumps into the light, attack him. Keep doing this until his and his wife's life runs out to complete the level.

Token collection:
While swinging through the city you might hear a chime. This indicates that you are close to a token.

Web swinging upgrades:
You can earn upgrades for this ability by using it a lot.

Traffic:
Throughout the game if you watch the traffic enough, other cars besides those of criminals will hit one another and dent up the rear of the car.

Play as pedestrian Peter Parker:
When there is a mission available for the Daily Bugle, go to it. Go inside the building and talk to Robbie. When he assigns you a project, leave the building and go back in. You will notice the nav point is now showing up from inside the building. Wait up to seven minutes inside the building. You will get a mission failed you wasted to much time, Eddie has taken your job. You have two options, 'Retry' or 'Do something else'. Select 'Do something else' and you should then appear on top of the Daily Bugle as Peter Parker. Walk over to the race on top of the building but do not start it. When you get the 'Press A to start mission' message you will now have the ability to use A, which is punch. Walk over to the edge of the building and hold Forward and do uppercuts until Peter falls off the building. You are now Peter Parker in the city. All you can do is run around and punch or web. To exit this mode, die. When you respawn on top of the building go in the Daily Bugle and come back out. Note: This was only tested as Dark Spider-Man but should work for both forms

Achievements:
Complete the following achievements to unlock Xbox Live Gamerscore points.

Police Sergeant 30 points: Complete all Bank Robbery missions.

Police Officer 30 points: Complete all Crime Spree missions.

Police Corporal 30 points: Complete all Petty Theft missions.

Cold Blooded Super Master 30 points: Complete all Connors missions.

Deputy 30 points: Complete all DeWolfe missions.

Frequent Flyer 10 points: Collect all Skyscraper tokens.

Splat Master 2007 20 points: Splat into the ground 25 times.

Police Detective 30 points: Complete 25 random city missions.

Police Chief 30 points: Complete all combat tours.

Punk Rocker 10 points: Collect all Apocalypse Gang tokens.

Sweet Tooth 10 points: Collect all Arsenic Candy tokens.

Fire Breather 10 points: Collect all Order of the Dragon Tail tokens.

Arachnophile 10 points: Collect all Secret tokens.

Pied Piper 10 points: Collect all Subway tokens.

Hitch Hiker 20 points: Ride a car or truck for 5 miles.

Eddie Brock 40 points: Defeat this nemesis.

Flint Marko 30 points: Defeat this nemesis.

Harry Osborn 30 points: Defeat this nemesis.

Wilson Fisk 30 points: Defeat this nemesis.

Aleksei Sytsevich 30 points: Defeat this nemesis.

Macdonald Gargan 40 points: Rescue this adversary.

Sergei Kravinoff 30 points: Defeat this nemesis.

Curtis Connors 30 points: Defeat this nemesis.

Luke Carlyle 30 points: Defeat this nemesis.

Gold Medal Winner 30 points: Get Gold on all trick races.

Silver Finalist 20 points: Get at least Silver on all trick races.

Bronze Finalist 20 points: Get at least Bronze on all trick races.

Trick Novice 20 points: Get at least Bronze on all easy trick races.

Mary Jane Thriller 20 points: Complete all Mary Jane thrill rides.

Bomb Squad 20 points: Get at least Bronze on all bomb tours.

Mega Tourist 10 points: Take a photograph from a great height.

Master Tourist 20 points: Take a 500-point photograph.

Shutterbug 20 points: Complete all Daily Bugle photo missions.

Web Slinger 20 points: Web up 25 enemies.

Fast Swinger 20 points: Swing at 200 miles per hour.

Pole Swinger 10 points: Swing on 50 poles.

Spider-Man 50 points: Complete all missions.

Collateral Damage 10 points: Destroy 25 objects.

A Dark Reward 20 points: Secret Achievement

Web Swinger 20 points: Swing a total of 10 miles.

Master Web Swinger 20 points: Swing a total of 50 miles.

Mega Web Swinger 30 points: Swing a total of 200 miles.

Intermediate Racer 20 points: Get at least Bronze on all easy and medium trick races.